Aminoglycoside Nephrotoxicity: Modeling, Simulation, and Control
نویسندگان
چکیده
منابع مشابه
Aminoglycoside nephrotoxicity: modeling, simulation, and control.
The main constraints on the administration of aminoglycosides are the risks of nephrotoxicity and ototoxicity, which can lead to acute, renal, vestibular, and auditory toxicities. In the present study we focused on nephrotoxicity. No reliable predictor of nephrotoxicity has been found to date. We have developed a deterministic model which describes the pharmacokinetic behavior of aminoglycoside...
متن کاملTitle : Aminoglycoside Nephrotoxicity: Modeling, Simulation and Control
Address: (1) ADCAPT, Service Pharmaceutique, Hôpital Antoine Charial, Francheville, France. (2) Université Paris−Sud, Laboratoire des Signaux et Systèmes (CNRS−SUPELEC), Gif−sur− Yvette, France. (3) INRETS, Bron, France. (4) Laboratoire GAGE, Ecole Polytechnique, Palaiseau, France. (5) Laboratory of Applied Pharmacokinetics, University of Southern California, School of Medicine, Los Angeles CA ...
متن کاملAminoglycoside nephrotoxicity
Aminoglycoside are frequently used due to its high efficacy against gram-negative bacteria and positive synergism with other antibiotics against gram-positive organisms. They are commonly used for prevention and treatment of infection complications after cardiothoracic surgery. The principal side effect of this class of antibiotics is nephrotoxicity, which may occur in up to 20% of the exposed ...
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*Corresponding author: Sandra Rodríguez Salgueiro, Electron Microscopy Laboratory, National Center for Scientific Research, Cubanacán, Havana, Cuba. E-mail: [email protected] Aminoglycosides are a family of antibiotics widely used in clinical practice. Their prescription is restricted by cytotoxicity and accumulation of antibiotic in renal tissues (1). Although renal damage induced b...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2003
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.47.3.1010-1016.2003